Advancing the science of Alzheimer's disease treatment through rigorous research and evidence-based approaches.
This preprint examines how exosomes isolated from young adult donors (ages 18-25) can reprogram gene expression patterns in aged brain endothelial cells, potentially reversing molecular signatures associated with Alzheimer's disease pathogenesis.
A comprehensive exploration of how vascular dysfunction, particularly endothelial cell impairment, plays a critical role in Alzheimer's disease pathogenesis. This paper examines the neurovascular unit, temporal dynamics of disease progression, and the promising therapeutic potential of exosomes derived from young donors.